Homocyst(e)ine and cardiovascular disease.
نویسنده
چکیده
Homocyst(e)ine is an amino acid made by the body during normal metabolism. An elevated blood level of homocyst(e)ine has been associated with atherosclerotic vascular disease (blockages of the arteries in the heart, brain and/or lower limbs) and venous thrombosis. Although the pathogenic mechanisms at work have not been defined, experimental evidence suggests that homocyst(e)ine damages the inner lining of the artery, and promotes thrombosis, possibly affecting blood coagulation.
منابع مشابه
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PURPOSE To review epidemiologic studies on the association between homocyst(e)ine level and risk for cardiovascular disease and the potential benefits of homocysteine-decreasing therapies. DATA SOURCES Computerized and manual searches of the literature on total homocysteine levels and cardiovascular disease. STUDY SELECTION Prospective studies and major retrospective epidemiologic studies e...
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عنوان ژورنال:
- Annals of internal medicine
دوره 132 8 شماره
صفحات -
تاریخ انتشار 2000